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KMID : 0363219930310010076
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Korean Journal of Dermatology
1993 Volume.31 No. 1 p.76 ~ p.82
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Distribution of the Deposits of Immunoglobulin, Fibrinogen and Fibronectin in psoriatic Lesions
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Abstract
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This study was conducted to observe immunological abnormalities, vascular changes and abnormal maturation pathway of keratinocyte in the psoriasis, by comparing deposits of IgG, fibrinogen(FG) and fibronectin(FN) in the involved and uninvolved
skin
of
19 psoriatics before treatment, the involved skin of 12 among the above patients after treatment, and the skin of 8 normal controls. The study was carried out by using direct immunofluorescence technique with anti-IgG, anti-FG, anti-FN
antibodies.
@ES The results are summarized as follows:
@EN 1. In the uninvolved skin of 19 psoriatics before treatment, no deposition of IgG was observed while deposition of FG was present at the dermo-epidermal junction in 5.3% of the patients and dermis(10.5%). Deposition of FN was found at the
dermo-epidermal junction(52.6%), papillary dermis(57.9%) and dermal blood vessels(52.6%)
2. In the involved skin of 19 psoriatics before treatment. Deposition of IgG was observed in the horny layer in 84.2% of the patients, upper epidermis(15.8%0 and deposition of FG was present in the horny layer(52.6%), upper epidermis(63.1%)
dermo-epidermal junction(15.8%), upper dermis(15.8%) and dermal blood vessels(5.3%). Deposition of FN was found in the hornylayer(26.3%), upper epidermis (36.8%), dermo-epidermal junction(78.9%), UPPER DERMIS(89.5%) and dermal blood
vessels(68.4%).
3. In the involved skin of 12 psoriatics after treatment, IgG was weakly deposited in the horny layer in 16.7% of the patients and deposition of FG was observed in the horny layer(8.3%), upper epidermis (16.7%), dermo-epidermal junction(8.3%)
and
dermis(8.3%). Deposition of FN was found in the upper epidermis(8.3%), dermo-epidermal junction(58.3%), dermis(66.7%) and dermal blood vessels (33.3%).
4. In the normal skin of 8 control subjects, no deposition of IgG and FG was observed while deposition of FN was found at the dermo-epidermal junction in 37.5% of the persons, upper dermis(25%)and dermal blood vessels(12.5%) (Kor J Dermatol 1993
;
31(1) : 76-82)
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